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KMID : 0377619680140010043
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Korean Jungang Medical Journal
1968 Volume.14 No. 1 p.43 ~ p.63
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Experimental Studies on the Metabolism of the Storage Iron in the Kidney
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Abstract
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The author, using white rabbits, studied. the metabolism of storage iron in the renal cortex and Medulla, liver, spleen, bone marrow and duodenum in normal untreated, anemic, and glycol or mercury poisoned groups not receiving iron. In addition, similar studies were made in groups receiving iron. The following results were obtained.
1. In the normal animal, the following points were observed.
a. The concentration of storage iron in the renal cortex is greater than that of the renal medulla.
b. The concentration of hemosiderin iron is greater than that of ferritin iron in both the renal cortex and medulla.
c. There is a positive correlation between the concentrations of storage iron in the renal cortex and medulla and also between the concentrations of hemosiderin iron and ferritin iron in the renal cortex.
2. In the animals made anemic by withdrawal of massive blood cells, in the poisoned animals with glycol or mercury, the concentration of storage iron in the kidney was decreased, especially in the cortex.
3. In the iron overloaded animals, the. following points were observed.
a. The content of the storage iron in the kidney is apparently increased in both the normal and the unilaterally nephrectomized animals.
b. The concentration of the renal storage iron is increased insignificantly in the glycol poisoned animal.
c. In the mercury poisoned animals, the renal storage iron shows a tendency of slight increase in the cortex and apparent increase in the medulla.
4. The ability of the kidney to deposit the loaded iron in the normal animals is not influenced by the iron context of the kidney prior to iron load.
5. The epithelium of the renal tubules is the structural element of the kidney which deposits iron, and more iron is deposited in the luminal portion than in the basal portion of the cytoplasm of the tubular epithelium.
6. The kidney is considered to be an organ of iron deposit as are the liver, spleen, and bone marrow.
7. The author would offer the following hypothesis about the metabolism of storage iron in the kidney. In the processes depositing or mobilizing iron in the tubular epithelium, the iron passes through the basal aspect of the epithelium and the iron excreted in the urine is mainly originated from the desquamated epithelium of the renal tubules.
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